2018英特爾ISEF學(xué)科最佳作品摘要：生物醫(yī)學(xué)與健康科學(xué) | Best of Category Abstract: BIOMEDICAL AND HEALTH SCIENCES

獲獎(jiǎng)作品基本信息

年份	2018
學(xué)科	生物醫(yī)學(xué)與健康科學(xué) BIOMEDICAL AND HEALTH SCIENCES
學(xué)校	University School of Milwaukee
國家/州	WI，United States of America

獲獎(jiǎng)作品名稱

Role of Telomerase in Vascular Function and Exploration of Mitochondrial Dynamics: A Novel Approach to Treatment of Vascular Dysfunction

獲獎(jiǎng)作品摘要

Coronary Artery Disease (CAD), an aging related detriment, is the most common cause of mortality in the world. In addition, chemotherapy jeopardizes cardiovascular integrity and was shown to be interconnected with CAD via RNAseq. Telomerase, an anti-aging related enzyme, is a nuclear derived telomere regulator and was hypothesized to mitigate the vascular effects of aforementioned ailments. Following creation of a specialized videomicrocopy apparatus, global activation of telomerase resulted in restored vascular function amidst CAD and chemotherapy. Separate from its conventional nuclear role, telomerase was shown to translocate to the mitochondria and preserve mitochondrial function. As global overexpression of telomerase is known to be oncogenic, a novel, clinically applicable mitochondrial telomerase decoy peptide was created in order to preserve therapeutic effects with minimal oncogenic activity. The decoy peptide restored vascular function and preserved cellular integrity amidst CAD, chemotherapy and vascular stressors. In order to accelerate telomerase-related drug development, a unique computational method using a developed at-home computational cluster was developed. Moreover, an ultra precise mechanistic mathematical model of the mitochondrial dynamics was created in order to simulate and predict novel mitochondrial telomerase interactions as well as further explore mitochondrial systems. This multidisciplinary study presents a revolutionary mechanism to combat CAD and preserve vascular function amidst chemotherapy. Additionally, the developed platform technologies have implications with many other diseases, representing a promising advancement to the biomedical field.

 

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ISEF 簡介

英特爾國際科學(xué)與工程大獎(jiǎng)賽，簡稱 "ISEF"，由美國 Society for Science and the Public（科學(xué)和公共服務(wù)協(xié)會(huì)）主辦，英特爾公司冠名贊助，是全球規(guī)模最大、等級(jí)最高的中學(xué)生的科研科創(chuàng)賽事。ISEF 的學(xué)術(shù)活動(dòng)學(xué)科包括了所有數(shù)學(xué)、自然科學(xué)、工程的全部領(lǐng)域和部分社會(huì)科學(xué)。ISEF 素有全球青少年科學(xué)學(xué)術(shù)活動(dòng)的“世界杯”之美譽(yù)，旨在鼓勵(lì)學(xué)生團(tuán)隊(duì)協(xié)作，開拓創(chuàng)新，長期專一深入地研究自己感興趣的課題。

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英特爾 ISEF 學(xué)術(shù)活動(dòng)詳細(xì)介紹

英特爾 ISEF 全程指導(dǎo)方案

· 數(shù)學(xué) · 物理 · 化學(xué) · 生物 · 計(jì)算機(jī) · 工程 ·

學(xué)科簡介：生物醫(yī)學(xué)與健康科學(xué) BIOMEDICAL AND HEALTH SCIENCES

This category focuses on studies specifically designed to address issues of human health and disease. It includes studies on the diagnosis, treatment, prevention or epidemiology of disease and other damage to the human body or mental systems. Includes studies of normal functioning and may investigate internal as well as external factors such as feedback mechanisms, stress or environmental impact on human health and disease.

Subcategories:

Cell, Organ, and Systems Physiology?(PHY):?These studies investigate mechanisms that are involved in maintaining health or when disrupted, cause disease. They could involve investigating such things as the role of cell signaling pathways both within the cell (intracellular) and/or between cells (extracellular). Alternatively, studies in this subcategory could investigate the maintenance of homeostasis at the organ or whole body level (e.g., hormonal control and regulation). These studies may also be in areas such as disease-related, stress-related, biochemical, mechanical, or physical changes at the tissue, organ, and /or cellular level.

Genetics and Molecular Biology of Disease?(GEN):?These studies investigate the genetic and molecular mechanisms involved in the regulatory pathways that maintain normal body and cellular function or if disturbed can lead to disease. Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.

Immunology?(IMM):?These studies will investigate any aspects of the immune system that are involved in maintaining health or when altered lead to pathology. These studies can include new investigations of normal immune function (e.g., immune cell interactions and signaling), or they may study diseases caused by disorders in regulation of the immune system (e.g., immunodeficiency or autoimmunity). Alternatively the studies could investigate problems such as graft vs host or host versus graft disease that arise during the treatment of other diseases or conditions.

Nutrition and Natural Products?(NTR):?The study of food, nutrients and dietary need in humans, and the effects of food and nourishment on the body. ?These studies may include the effects of natural or supplemental nutrients and nutrition.

Pathophysiology?(PAT):?These studies will be focused on determining specific causes of disease and on physiological mechanisms responsible for disease development. Investigations in this category will examine changes in the normal physiological balance, or homeostasis that cause a reaction(s) within the body leading to disease.

Other?(OTH):?Studies that cannot be assigned to one of the above subcategories.?If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.